Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 9/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.48 |
| ▸ | STS | P08842 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20010589 | 1.00 | HSD17B10 (0.49) | HSD17B10TSHRMAPK1AKR1C3ESR1 | |
| SCHEMBL20010697 | 0.90 | ESR1 (0.61) | HSD17B10TSHRMAPK1AKR1C3ESR1 | |
| SCHEMBL20015657 | 0.90 | ESR1 (0.61) | HSD17B10TSHRMAPK1AKR1C3ESR1 | |
| SCHEMBL24399389 | 0.90 | ESR1 (0.61) | HSD17B10TSHRMAPK1AKR1C3ESR1 | |
| SCHEMBL20010592 | 0.88 | ESR1 (0.47) | HSD17B10TSHRMAPK1AKR1C3ESR1 | |
| SCHEMBL25863861 | 0.83 | ESR1 (0.54) | HSD17B10TSHRMAPK1AKR1C3ESR1 | |
| SCHEMBL25863898 | 0.83 | ESR1 (0.54) | HSD17B10TSHRMAPK1AKR1C3ESR1 | |
| SCHEMBL20010588 | 0.82 | ESR1 (0.42) | HSD17B10TSHRMAPK1AKR1C3ESR1 | |
| SCHEMBL19644038 | 0.82 | ESR1 (0.60) | HSD17B10TSHRMAPK1AKR1C3ESR1 | |
| SCHEMBL19644037 | 0.82 | ESR1 (0.60) | HSD17B10TSHRMAPK1AKR1C3ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086787-A1 | ESTROGEN RECEPTOR MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086787-A1 | ESTROGEN RECEPTOR MODULATORS | ESR2, ESRRA, ESRRB | HSD17B10 578/4885TSHR 420/4885MAPK1 2894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.