Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24700443 | 0.69 | CYP2C9 (0.41) | CYP2C9TSHRCYP2C19TDP1 | |
| Fluoride SCHEMBL11256207 | 0.67 | TP53 (0.36) | — | |
| SCHEMBL25690956 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL23123878 | 0.67 | CYP2C9 (0.39) | CYP2C9TSHRCYP2C19TDP1 | |
| SCHEMBL19318257 | 0.65 | — | — | |
| SCHEMBL18256132 | 0.64 | — | — | |
| SCHEMBL24342600 | 0.64 | — | — | |
| SCHEMBL14110736 | 0.64 | — | — | |
| SCHEMBL81819 | 0.64 | — | — | |
| SCHEMBL13116775 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3174881-B1 | [1,2,4]TRIAZOLO[4,3-B]PYRIDAZINES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2018-03-28 | — | — | EP | disclosed |