Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20017572 | 1.00 | PIM1 (0.42) | PIM1PTPN11GAACYP2C9CYP3A4 | |
| SCHEMBL15608608 | 0.88 | PIM1 (0.42) | PIM1GAACYP2C9CYP3A4POLB | |
| SCHEMBL15625142 | 0.88 | PIM1 (0.42) | PIM1GAACYP2C9CYP3A4POLB | |
| SCHEMBL15625073 | 0.88 | PIM1 (0.42) | PIM1GAACYP2C9CYP3A4POLB | |
| SCHEMBL15625114 | 0.82 | PIM1 (0.31) | PIM1MEN1KMT2A | |
| SCHEMBL15625058 | 0.82 | PIM1 (0.31) | PIM1MEN1KMT2A | |
| SCHEMBL15608701 | 0.82 | PIM1 (0.31) | PIM1MEN1KMT2A | |
| SCHEMBL21553248 | 0.80 | PIM1 (0.40) | PIM1GAACYP2C9CYP3A4POLB | |
| SCHEMBL21553240 | 0.79 | MEN1 (0.38) | GAACYP2C9CYP3A4POLBCYP1A2 | |
| SCHEMBL15625075 | 0.79 | PIM1 (0.37) | PIM1GAACYP2C9CYP3A4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963446-B2 | Oxepan-2-yl-pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use | GENENTECH, INC. (US) | 2018-05-08 | — | — | US | disclosed |
| US-9931323-B2 | Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use | GENENTECH, INC. (US) | 2018-04-03 | — | — | US | disclosed |