Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 20/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14908080 | 0.88 | MAPK1 (0.62) | MAPK1 | |
| SCHEMBL22166077 | 0.84 | MAPK1 (0.56) | MAPK1 | |
| SCHEMBL22166076 | 0.84 | MAPK1 (0.59) | MAPK1 | |
| SCHEMBL22166082 | 0.83 | MAPK1 (0.64) | MAPK1 | |
| SCHEMBL12073200 | 0.81 | MAPK1 (0.58) | MAPK1 | |
| SCHEMBL29988291 | 0.81 | MAPK1 (0.58) | MAPK1 | |
| SCHEMBL29988595 | 0.80 | MAP2K4 (0.59) | MAPK1 | |
| SCHEMBL14908043 | 0.79 | MAPK1 (1.00) | MAPK1 | |
| SCHEMBL4222590 | 0.78 | AXL (0.55) | MAPK1 | |
| SCHEMBL7920974 | 0.77 | ADORA2A (0.47) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2770987-B1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2018-04-04 | — | — | EP | disclosed |