Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324694 | 0.82 | PIK3R1 (0.55) | HTR2CACKR3KDM4EGAA | |
| SCHEMBL5496661 | 0.82 | HTR2C (0.65) | HTR2C | |
| SCHEMBL9963421 | 0.81 | PDE10A (0.42) | HTR2CACKR3TSHR | |
| Hydrochloric Acid SCHEMBL11172195 | 0.80 | HTR2C (0.61) | HTR2C | |
| SCHEMBL2312218 | 0.80 | ACKR3 (0.44) | ACKR3KDM4EALDH1A1GLAGAA | |
| SCHEMBL19222166 | 0.76 | GRIA1 (0.43) | HTR2C | |
| SCHEMBL17793382 | 0.73 | HTR2C (0.45) | HTR2CACKR3 | |
| SCHEMBL19468828 | 0.73 | HTR2C (0.45) | HTR2CACKR3 | |
| SCHEMBL15754793 | 0.73 | ACKR3 (0.46) | ACKR3 | |
| SCHEMBL15760247 | 0.73 | ACKR3 (0.48) | ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564235-A1 | SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING KINASE 1 (MNK1) AND 2 (MNK2) | Northwestern University (US) | 2019-11-06 | — | — | EP | disclosed |
| EP-2925745-B1 | CXCR7 ANTAGONISTS | CHEMOCENTRYX INC (US) | 2018-04-04 | — | — | EP | disclosed |