Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 17/20 | 0.63 |
| ▸ | PSEN2 | P49810 | 17/20 | 0.63 |
| ▸ | APH1B | Q8WW43 | 17/20 | 0.63 |
| ▸ | NCSTN | Q92542 | 17/20 | 0.63 |
| ▸ | APH1A | Q96BI3 | 17/20 | 0.63 |
| ▸ | PSENEN | Q9NZ42 | 17/20 | 0.63 |
| ▸ | APP | P05067 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20021775 | 0.90 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20021474 | 0.87 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17723292 | 0.81 | PSEN1 (0.66) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17723293 | 0.81 | PSEN1 (0.87) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29550134 | 0.81 | PSEN1 (0.87) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17714377 | 0.81 | PSEN1 (0.87) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17723387 | 0.81 | PSEN1 (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17714376 | 0.81 | PSEN1 (0.87) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20021831 | 0.80 | PSEN1 (0.64) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28411825 | 0.79 | PSEN1 (0.75) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11117884-B2 | Potent gamma-secretase modulators | THE GENERAL HOSPITAL CORPORATION (US) | 2021-09-14 | — | — | US | disclosed |
| CN-107406423-B | Potent gamma-secretase modulators | 通用医疗公司 | 2020-06-16 | — | — | CN | disclosed |
| US-20200055840-A1 | POTENT GAMMA-SECRETASE MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-02-20 | — | — | US | disclosed |
| US-10472346-B2 | Potent gamma-secretase modulators | THE GENERAL HOSPITAL CORPORATION (US) | 2019-11-12 | — | — | US | disclosed |
| US-20180093967-A1 | POTENT GAMMA-SECRETASE MODULATORS | THE GENERAL HOSPITAL CORPORATION | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200055840-A1 | POTENT GAMMA-SECRETASE MODULATORS | BACE1, BACE2, GSAP | PSEN1 6/4885PSEN2 8/4885APH1B 7/4885 |
| US-10472346-B2 | Potent gamma-secretase modulators | BACE1, BACE2, APP | PSEN1 4/4885PSEN2 7/4885APH1B 8/4885 |
| US-11117884-B2 | Potent gamma-secretase modulators | BACE1, BACE2, GSAP | PSEN1 6/4885PSEN2 8/4885APH1B 7/4885 |
| US-20180093967-A1 | POTENT GAMMA-SECRETASE MODULATORS | BACE1, BACE2, APP | PSEN1 4/4885PSEN2 7/4885APH1B 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.