Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 9/20 | 0.80 |
| ▸ | CLK2 | P49760 | 9/20 | 0.80 |
| ▸ | CLK4 | Q9HAZ1 | 9/20 | 0.80 |
| ▸ | CDK1 | P06493 | 7/20 | 0.73 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.68 |
| ▸ | CDK4 | P11802 | 2/20 | 0.68 |
| ▸ | CCND3 | P30281 | 1/20 | 0.68 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
| ▸ | MERTK | Q12866 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.58 |
| ▸ | CDK2 | P24941 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.58 |
| ▸ | PAK4 | O96013 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20027789 | 1.00 | CLK1 (0.80) | CLK1CLK2CLK4CDK1CCNB1 | |
| SCHEMBL20027791 | 1.00 | CLK1 (0.80) | CLK1CLK2CLK4CDK1CCNB1 | |
| SCHEMBL20027793 | 0.95 | CLK1 (0.79) | CLK1CLK2CLK4CDK1CCNB1 | |
| SCHEMBL20027792 | 0.95 | CLK1 (0.79) | CLK1CLK2CLK4CDK1CCNB1 | |
| SCHEMBL20028201 | 0.95 | CLK1 (0.79) | CLK1CLK2CLK4CDK1CCNB1 | |
| SCHEMBL21282798 | 0.91 | CLK1 (0.72) | CLK1CLK2CLK4CDK1CCNB1 | |
| SCHEMBL21282792 | 0.91 | CLK1 (0.71) | CLK1CLK2CLK4CDK1CCNB1 | |
| SCHEMBL22783739 | 0.91 | CLK1 (0.71) | CLK1CLK2CLK4CDK1CCNB1 | |
| SCHEMBL20028328 | 0.89 | CLK1 (1.00) | CLK1CLK2CLK4CDK1CCNB1 | |
| SCHEMBL20027887 | 0.89 | CLK1 (1.00) | CLK1CLK2CLK4CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018064545-A1 | DUAL CLK/CDK1 INHIBITORS FOR CANCER TREATMENT | SRI INTERNATIONAL (US) | 2018-04-05 | — | — | WO | disclosed |