Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 8/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20028692 | 1.00 | USP30 (0.41) | USP30BACE1BACE2MTORPRMT5 | |
| SCHEMBL21167236 | 0.92 | USP30 (0.34) | USP30BACE1BACE2MTORPRMT5 | |
| SCHEMBL21145359 | 0.87 | USP30 (0.39) | USP30BACE1BACE2 | |
| SCHEMBL21145361 | 0.87 | USP30 (0.39) | USP30BACE1BACE2 | |
| SCHEMBL20028889 | 0.84 | USP30 (0.47) | USP30BACE1MTORPIK3CAGPR119 | |
| SCHEMBL20028690 | 0.84 | USP30 (0.47) | USP30BACE1MTORPIK3CAGPR119 | |
| SCHEMBL14158758 | 0.80 | USP30 (0.49) | USP30PIK3CAGPR119 | |
| SCHEMBL20028691 | 0.77 | USP30 (0.50) | USP30MTORPIK3CAGPR119SCD5 | |
| SCHEMBL28779045 | 0.77 | USP30 (0.50) | USP30MTORPIK3CAGPR119SCD5 | |
| SCHEMBL20028892 | 0.77 | USP30 (0.66) | USP30PIK3CAGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109790148-B | Cyano-substituted heterocycles having USP30 inhibitor activity | 特殊治疗有限公司 | 2022-06-07 | — | — | CN | disclosed |
| WO-2018060691-A1 | CYANO-SUBTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LIMITED (GB) | 2018-04-05 | — | — | WO | disclosed |