Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 9/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20029001 | 0.88 | USP30 (0.65) | USP30GPR119 | |
| SCHEMBL20029002 | 0.88 | USP30 (0.65) | USP30GPR119 | |
| SCHEMBL29679555 | 0.87 | USP30 (0.46) | USP30GPR119SCD5 | |
| SCHEMBL20028867 | 0.87 | USP30 (0.46) | USP30GPR119SCD5 | |
| SCHEMBL20028870 | 0.87 | USP30 (0.46) | USP30GPR119SCD5 | |
| SCHEMBL21145375 | 0.86 | USP30 (0.53) | USP30PDK2 | |
| SCHEMBL21145374 | 0.86 | USP30 (0.53) | USP30PDK2 | |
| SCHEMBL20028871 | 0.84 | USP30 (0.67) | USP30GPR119 | |
| SCHEMBL20028897 | 0.84 | USP30 (0.60) | USP30SCD5PDK2 | |
| SCHEMBL20028902 | 0.82 | USP30 (0.67) | USP30GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109790148-B | Cyano-substituted heterocycles having USP30 inhibitor activity | 特殊治疗有限公司 | 2022-06-07 | — | — | CN | disclosed |
| EP-3519397-B1 | CYANO-SUBTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LTD (GB) | 2021-05-19 | — | — | EP | disclosed |
| WO-2018060691-A1 | CYANO-SUBTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LIMITED (GB) | 2018-04-05 | — | — | WO | disclosed |