Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 18/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20023965 | 0.85 | CFTR (0.39) | CFTR | |
| SCHEMBL20029455 | 0.81 | CFTR (0.40) | CFTR | |
| SCHEMBL20029658 | 0.79 | CFTR (0.40) | CFTR | |
| SCHEMBL21274809 | 0.78 | CFTR (0.40) | CFTR | |
| SCHEMBL26809680 | 0.76 | CFTR (0.33) | CFTR | |
| SCHEMBL20029801 | 0.75 | CFTR (0.40) | CFTR | |
| SCHEMBL21245122 | 0.74 | CFTR (0.36) | CFTR | |
| SCHEMBL22996171 | 0.74 | CFTR (0.34) | CFTR | |
| SCHEMBL21245086 | 0.74 | CFTR (0.32) | CFTR | |
| SCHEMBL21244472 | 0.73 | CFTR (0.32) | CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3519401-B1 | MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR | VERTEX PHARMA (US) | 2021-09-29 | — | — | EP | disclosed |
| WO-2018064632-A1 | MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-04-05 | — | — | WO | disclosed |