Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20031163 | 1.00 | HTR1D (0.40) | HTR1DHTR1BATML3MBTL1TAAR1 | |
| SCHEMBL24080193 | 0.92 | HTR1D (0.41) | HTR1DHTR1BL3MBTL1TAAR1TSHR | |
| SCHEMBL20030610 | 0.92 | HTR1D (0.41) | HTR1DHTR1BL3MBTL1TAAR1TSHR | |
| SCHEMBL20030623 | 0.90 | HTR1D (0.40) | HTR1DHTR1BATML3MBTL1TAAR1 | |
| SCHEMBL20030624 | 0.90 | HTR1D (0.40) | HTR1DHTR1BATML3MBTL1TAAR1 | |
| SCHEMBL20031152 | 0.82 | HTR1D (0.41) | HTR1DHTR1BL3MBTL1TAAR1TSHR | |
| SCHEMBL20031058 | 0.82 | TSHR (0.50) | L3MBTL1TAAR1TSHRRECQLHTR1A | |
| SCHEMBL20031061 | 0.82 | TSHR (0.50) | L3MBTL1TAAR1TSHRRECQLHTR1A | |
| SCHEMBL19812818 | 0.76 | TAAR1 (0.55) | HTR1DHTR1BL3MBTL1TAAR1TSHR | |
| SCHEMBL19812820 | 0.76 | TAAR1 (0.55) | HTR1DHTR1BL3MBTL1TAAR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220185799-A1 | 1-HETEROCYCLYL ISOCHROMANYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS | SUNOVION PHARMACEUTICALS INC. (US) | 2022-06-16 | — | — | US | disclosed |
| US-10336732-B2 | 1-heterocyclyl isochromanyl compounds and analogs for treating CNS disorders | SUNOVION PHARMACEUTICALS INC. (US) | 2019-07-02 | — | — | US | disclosed |
| US-20180093974-A1 | 1-HETEROCYCLYL ISOCHROMANYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS | SUNOVION PHARMACEUTICALS INC. (US) | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180093974-A1 | 1-HETEROCYCLYL ISOCHROMANYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS | CNR1, HCRTR1, CNR2 | HTR1D 52/4885HTR1B 34/4885ATM 1555/4885 |
| US-20220185799-A1 | 1-HETEROCYCLYL ISOCHROMANYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS | CNR1, HCRTR1, CNR2 | HTR1D 52/4885HTR1B 34/4885ATM 1555/4885 |
| US-10336732-B2 | 1-heterocyclyl isochromanyl compounds and analogs for treating CNS disorders | CNR1, HCRTR1, CNR2 | HTR1D 52/4885HTR1B 34/4885ATM 1555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.