Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 11/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22126591 | 1.00 | NAMPT (0.41) | NAMPTUSP30AKR1C3FPR2HDAC8 | |
| SCHEMBL22126608 | 0.84 | USP30 (0.47) | USP30AKR1C3 | |
| SCHEMBL20031446 | 0.83 | USP30 (0.59) | NAMPTUSP30HDAC8HDAC6PIK3R1 | |
| SCHEMBL20031444 | 0.83 | USP30 (0.59) | NAMPTUSP30HDAC8HDAC6PIK3R1 | |
| SCHEMBL22126589 | 0.81 | NAMPT (0.40) | NAMPTUSP30 | |
| SCHEMBL20031592 | 0.81 | NAMPT (0.40) | NAMPTUSP30 | |
| SCHEMBL31200501 | 0.81 | NAMPT (0.40) | NAMPTUSP30 | |
| SCHEMBL20031442 | 0.80 | USP30 (0.67) | USP30 | |
| SCHEMBL20031537 | 0.79 | USP30 (0.66) | NAMPTUSP30HDAC8HDAC6 | |
| SCHEMBL20031533 | 0.79 | USP30 (0.66) | NAMPTUSP30HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3519412-B1 | CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LTD (GB) | 2021-12-01 | — | — | EP | disclosed |
| WO-2018060742-A1 | CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LIMITED (GB) | 2018-04-05 | — | — | WO | disclosed |