SCHEMBL20031584

SCHEMBL20031584

N#Cc1cccc(-c2ccc(N3CCOC4CN(C#N)CC43)nc2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
USP30 Q70CQ3 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20031583 1.00 USP30 (1.00) USP30
SCHEMBL22126596 0.89 USP30 (1.00) USP30
SCHEMBL22126598 0.89 USP30 (1.00) USP30
SCHEMBL22126590 0.88 USP30 (1.00) USP30
SCHEMBL20031359 0.88 USP30 (1.00) USP30
SCHEMBL20031357 0.88 USP30 (1.00) USP30
SCHEMBL22126594 0.87 USP30 (1.00) USP30
SCHEMBL20031113 0.87 USP30 (1.00) USP30
SCHEMBL29545908 0.87 USP30 (1.00) USP30
SCHEMBL20031114 0.87 USP30 (1.00) USP30

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3519412-B1 CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 MISSION THERAPEUTICS LTD (GB) 2021-12-01 EP disclosed
WO-2018060742-A1 CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 MISSION THERAPEUTICS LIMITED (GB) 2018-04-05 WO disclosed