Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24662745 | 0.90 | AHR (0.48) | MAPTKDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL22703059 | 0.88 | AHR (0.54) | ALDH1A1LMNAAHRKMT2A | |
| SCHEMBL22703014 | 0.88 | KDM4E (0.61) | MAPTKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL24564907 | 0.87 | MAPT (0.50) | MAPTKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL16548074 | 0.81 | TDP1 (0.47) | MAPTKDM4EHTTHSD17B10AHR | |
| SCHEMBL24662751 | 0.79 | MAPT (0.46) | MAPTKDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL24663158 | 0.78 | AHR (0.46) | MAPTKDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL24663163 | 0.78 | AHR (0.46) | MAPTKDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL23203595 | 0.78 | TTR (0.47) | MAPTKDM4EALDH1A1AHRMEN1 | |
| SCHEMBL23564313 | 0.78 | AR (0.38) | MAPTKDM4EALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3518746-B1 | [5]HELICENE DERIVATIVES AS MOLECULAR REPORTERS FOR DIAGNOSTIC APPLICATIONS AND METHODS OF SYNTHESIS THEREFOR | NATIONAL SCIENCE AND TECH DEVELOPMENT AGENCY (TH) | 2020-11-25 | — | — | EP | disclosed |
| WO-2018063105-A1 | [5]HELICENE DERIVATIVES AS MOLECULAR REPORTERS FOR DIAGNOSTIC APPLICATIONS AND METHODS OF SYNTHESIS THEREFOR | NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY (TH) | 2018-04-05 | — | — | WO | disclosed |