Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 8/20 | 0.45 |
| ▸ | CA12 | O43570 | 7/20 | 0.45 |
| ▸ | CA2 | P00918 | 7/20 | 0.45 |
| ▸ | CA1 | P00915 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18241606 | 0.90 | CA9 (0.41) | CA9CA12CA2CA1TSHR | |
| SCHEMBL11429924 | 0.88 | CA9 (0.40) | CA9CA12CA2CA1TSHR | |
| SCHEMBL20713534 | 0.88 | CA9 (0.40) | CA9CA12CA2CA1TSHR | |
| SCHEMBL11429920 | 0.88 | CA9 (0.40) | CA9CA12CA2CA1TSHR | |
| SCHEMBL7148709 | 0.87 | CA9 (0.39) | CA9CA12CA2CA1TSHR | |
| SCHEMBL18241580 | 0.87 | CA9 (0.39) | CA9CA12CA2CA1TSHR | |
| SCHEMBL7148711 | 0.87 | CA9 (0.39) | CA9CA12CA2CA1TSHR | |
| SCHEMBL7155715 | 0.85 | CA9 (0.38) | CA9CA12CA2CA1TSHR | |
| SCHEMBL7155215 | 0.82 | CA9 (0.38) | CA9CA12CA2CA1TSHR | |
| SCHEMBL7155711 | 0.81 | CA9 (0.38) | CA9CA12CA2CA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9937194-B1 | Compounds and methods for treating inflammatory diseases | CEMPRA PHARMACEUTICALS, INC. (US) | 2018-04-10 | — | — | US | disclosed |