Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 18/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20036661 | 0.87 | FFAR1 (0.58) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL20036612 | 0.84 | FFAR1 (0.43) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL20041221 | 0.80 | FFAR1 (0.47) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL20036617 | 0.79 | FFAR1 (0.39) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL19788647 | 0.78 | FFAR1 (0.67) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL20036604 | 0.78 | FFAR1 (0.67) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL20036595 | 0.78 | FFAR1 (0.67) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL20036601 | 0.78 | FFAR1 (0.56) | FFAR1 | |
| SCHEMBL20036577 | 0.78 | FFAR1 (0.56) | FFAR1 | |
| SCHEMBL20036630 | 0.77 | FFAR1 (0.54) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3140296-B1 | PYRROLIDINE GPR40 MODULATORS FOR THE TREATMENT OF DISEASES SUCH AS DIABETES | BRISTOL MYERS SQUIBB CO (US) | 2018-04-11 | — | — | EP | disclosed |