Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.78 |
| ▸ | HCK | P08631 | 17/20 | 0.78 |
| ▸ | MAPK12 | P53778 | 17/20 | 0.78 |
| ▸ | SRC | P12931 | 3/20 | 0.65 |
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20036726 | 0.93 | MAPK14 (0.67) | MAPK14HCKMAPK12SRCSYK | |
| SCHEMBL20036765 | 0.92 | MAPK14 (0.66) | MAPK14HCKMAPK12SRCSYK | |
| SCHEMBL20036739 | 0.91 | MAPK14 (0.78) | MAPK14HCKMAPK12SRCSYK | |
| SCHEMBL14701111 | 0.91 | MAPK14 (0.77) | MAPK14HCKMAPK12SRCTNF | |
| SCHEMBL20060711 | 0.91 | MAPK14 (0.65) | MAPK14HCKMAPK12SRCSYK | |
| SCHEMBL20036743 | 0.90 | MAPK14 (0.78) | MAPK14HCKMAPK12SRCSYK | |
| SCHEMBL20036727 | 0.89 | MAPK14 (0.69) | MAPK14HCKMAPK12SRCSYK | |
| SCHEMBL20036717 | 0.89 | MAPK14 (0.69) | MAPK14HCKMAPK12SRCSYK | |
| SCHEMBL20036766 | 0.88 | MAPK14 (0.79) | MAPK14HCKMAPK12SRCGSK3B | |
| SCHEMBL2406393 | 0.88 | MAPK14 (1.00) | MAPK14HCKMAPK12SRCSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509595-B1 | INHIBITORS OF HEMOPOIETIC CELL KINASE (P59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION | RESPIVERT LTD (GB) | 2018-04-11 | — | — | EP | disclosed |