Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK6 | Q92876 | 10/20 | 0.74 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.62 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.62 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.62 |
| ▸ | KLK7 | P49862 | 1/20 | 0.62 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.62 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037215 | 0.89 | KLK6 (0.78) | KLK6RAB9APRSS1PRSS2PRSS3 | |
| SCHEMBL20037303 | 0.88 | KLK6 (0.74) | KLK6RAB9APRSS1PRSS2PRSS3 | |
| SCHEMBL20037090 | 0.87 | KLK6 (0.75) | KLK6RAB9APRSS1PRSS2PRSS3 | |
| SCHEMBL20037097 | 0.87 | KLK6 (0.75) | KLK6RAB9APRSS1PRSS2PRSS3 | |
| SCHEMBL20037170 | 0.87 | KLK6 (0.75) | KLK6RAB9APRSS1PRSS2PRSS3 | |
| SCHEMBL20037064 | 0.86 | KLK6 (0.74) | KLK6RAB9APRSS1PRSS2PRSS3 | |
| SCHEMBL20037216 | 0.85 | KLK6 (1.00) | KLK6RAB9APRSS1PRSS2PRSS3 | |
| SCHEMBL20037081 | 0.85 | KLK6 (0.72) | KLK6PRSS1PRSS2PRSS3KLK7 | |
| SCHEMBL20037031 | 0.84 | KLK6 (0.71) | KLK6RAB9APRSS1PRSS2PRSS3 | |
| SCHEMBL20037107 | 0.84 | KLK6 (0.84) | KLK6RAB9APRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018065607-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2018-04-12 | — | — | WO | disclosed |
| EP-3305781-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN-RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum (DE) | 2018-04-11 | — | — | EP | disclosed |