Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.49 |
| ▸ | KLK6 | Q92876 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037275 | 0.93 | KLK6 (0.54) | PRSS1PRSS2PRSS3KLK6ALDH1A1 | |
| SCHEMBL20037004 | 0.91 | PRSS1 (0.51) | PRSS1PRSS2PRSS3KLK6ALDH1A1 | |
| SCHEMBL20037222 | 0.88 | PRSS1 (0.49) | PRSS1PRSS2PRSS3KLK6ALDH1A1 | |
| SCHEMBL20037067 | 0.86 | PRSS1 (0.52) | PRSS1PRSS2PRSS3KLK6ALDH1A1 | |
| SCHEMBL20037199 | 0.85 | PRSS1 (0.47) | PRSS1PRSS2PRSS3KLK6ALDH1A1 | |
| SCHEMBL20037282 | 0.85 | PRSS1 (0.47) | PRSS1PRSS2PRSS3KLK6ALDH1A1 | |
| SCHEMBL20037040 | 0.85 | PRSS1 (0.47) | PRSS1PRSS2PRSS3KLK6ALDH1A1 | |
| SCHEMBL20037065 | 0.84 | KLK6 (0.49) | PRSS1PRSS2PRSS3KLK6ALDH1A1 | |
| SCHEMBL20037225 | 0.83 | PRSS1 (0.45) | PRSS1PRSS2PRSS3KLK6ALDH1A1 | |
| SCHEMBL20037036 | 0.83 | KLK6 (0.47) | PRSS1PRSS2PRSS3KLK6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018065607-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2018-04-12 | — | — | WO | disclosed |
| EP-3305781-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN-RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum (DE) | 2018-04-11 | — | — | EP | disclosed |