Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK6 | Q92876 | 6/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.59 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.59 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037103 | 0.91 | KLK6 (0.64) | KLK6PRSS1PRSS2PRSS3MEN1 | |
| SCHEMBL20037144 | 0.86 | KLK6 (0.62) | KLK6PRSS1PRSS2PRSS3MEN1 | |
| SCHEMBL20037280 | 0.85 | KLK6 (0.82) | KLK6PRSS1PRSS2PRSS3MEN1 | |
| SCHEMBL20037005 | 0.75 | KLK6 (0.89) | KLK6PRSS1PRSS2PRSS3MEN1 | |
| SCHEMBL20037270 | 0.75 | KLK6 (1.00) | KLK6PRSS1PRSS2PRSS3MEN1 | |
| SCHEMBL20037221 | 0.74 | KLK6 (0.86) | KLK6PRSS1PRSS2PRSS3MEN1 | |
| SCHEMBL20037080 | 0.73 | KLK6 (0.82) | KLK6PRSS1PRSS2PRSS3MEN1 | |
| SCHEMBL20037050 | 0.73 | KLK6 (0.71) | KLK6PRSS1PRSS2PRSS3MEN1 | |
| SCHEMBL20037182 | 0.73 | KLK6 (0.79) | KLK6PRSS1PRSS2PRSS3MEN1 | |
| SCHEMBL20037009 | 0.72 | KLK6 (0.73) | KLK6PRSS1PRSS2PRSS3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305781-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN-RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum (DE) | 2018-04-11 | — | — | EP | disclosed |