SCHEMBL20037286

SCHEMBL20037286

CC(=N)/C(N)=C(/C)Nc1cccc(C)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.57
HSD17B10 Q99714 1/20 0.54
SIGMAR1 Q99720 2/20 0.50
GRIN2D O15399 1/20 0.50
GRIN3B O60391 1/20 0.50
GRIN1 Q05586 1/20 0.50
GRIN2A Q12879 1/20 0.50
GRIN2B Q13224 1/20 0.50
GRIN2C Q14957 1/20 0.50
GRIN3A Q8TCU5 1/20 0.50
KMT2A Q03164 5/20 0.46
MEN1 O00255 4/20 0.46
MAPT P10636 3/20 0.46
ALDH1A1 P00352 2/20 0.46
GAA P10253 2/20 0.46
RXFP1 Q9HBX9 1/20 0.46
CYP2D6 P10635 2/20 0.46
POLB P06746 1/20 0.46
CRHBP P24387 1/20 0.46
CRHR2 Q13324 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1740852 0.80 CYP1A2 (0.67) CYP1A2HSD17B10SIGMAR1GRIN2DGRIN3B
SCHEMBL20048456 0.79 TDP1 (0.48) CYP1A2SIGMAR1GRIN2DGRIN3BGRIN1
SCHEMBL6422898 0.76 HSD17B10 (0.62) CYP1A2HSD17B10SIGMAR1GRIN2DGRIN3B
SCHEMBL1741887 0.75 CYP1A2 (0.59) CYP1A2HSD17B10SIGMAR1GRIN2DGRIN3B
SCHEMBL20037194 0.74 HSD17B10 (0.51) CYP1A2HSD17B10KMT2AMEN1MAPT
Hydrochloric Acid SCHEMBL28340523 0.73 CYP1A2 (0.57) CYP1A2HSD17B10SIGMAR1GRIN2DGRIN3B
SCHEMBL22995856 0.73 CYP1A2 (0.67) CYP1A2HSD17B10SIGMAR1GRIN2DGRIN3B
SCHEMBL1886408 0.73 CYP1A2 (1.00) CYP1A2HSD17B10SIGMAR1GRIN2DGRIN3B
SCHEMBL166848 0.73 HSD17B10 (0.69) CYP1A2HSD17B10SIGMAR1GRIN2DGRIN3B
SCHEMBL14432349 0.73 HSD17B10 (0.58) CYP1A2HSD17B10SIGMAR1GRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018065607-A1 CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN RELATED PEPTIDASE 6 (KLK6) Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 2018-04-12 WO disclosed
EP-3305781-A1 CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN-RELATED PEPTIDASE 6 (KLK6) Deutsches Krebsforschungszentrum (DE) 2018-04-11 EP disclosed