Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17054985 | 0.84 | KIT (0.41) | MAPK1MEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL21606946 | 0.80 | BRD4 (0.46) | HRH3PLK4CTSLCTSBCTSS | |
| SCHEMBL7105363 | 0.80 | IKBKB (0.43) | HRH3PLK4CTSLCTSBCTSS | |
| SCHEMBL2233319 | 0.77 | PLK4 (0.54) | HRH3PLK4CTSLCTSBCTSS | |
| SCHEMBL24529842 | 0.76 | PIK3CA (0.52) | CTSLCTSBCTSSCTSKMAPK1 | |
| SCHEMBL26330921 | 0.76 | BRD4 (0.47) | CTSLCTSBCTSSCTSKCDK4 | |
| SCHEMBL28823771 | 0.76 | CHEK1 (0.60) | CTSLCTSBCTSSCTSKCHEK1 | |
| SCHEMBL31247376 | 0.76 | HDAC1 (0.36) | PLK4NOS2 | |
| Hydrochloric Acid SCHEMBL25221350 | 0.75 | BRD4 (0.47) | CTSLCTSBCTSSCTSKCDK4 | |
| Hydrochloric Acid SCHEMBL22031708 | 0.75 | CHEK1 (0.45) | HRH3PLK4CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |