Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | GLI1 | P08151 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | ARG1 | P05089 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15173701 | 1.00 | EPHX1 (0.47) | EPHX1KMT2AMEN1BLMKDM4E | |
| SCHEMBL15173700 | 1.00 | EPHX1 (0.47) | EPHX1KMT2AMEN1BLMKDM4E | |
| SCHEMBL883229 | 0.87 | — | — | |
| SCHEMBL1054734 | 0.87 | — | — | |
| SCHEMBL1073392 | 0.87 | — | — | |
| SCHEMBL1080236 | 0.85 | SLC1A2 (0.43) | EPHX1KMT2AMEN1BLMKDM4E | |
| SCHEMBL29053592 | 0.81 | MEN1 (0.61) | EPHX1KMT2AMEN1BLMSLC1A2 | |
| SCHEMBL220787 | 0.81 | MEN1 (0.61) | EPHX1KMT2AMEN1BLMSLC1A2 | |
| SCHEMBL8383293 | 0.81 | MEN1 (0.45) | EPHX1KMT2AMEN1BLMNOS2 | |
| SCHEMBL220789 | 0.81 | MEN1 (0.61) | EPHX1KMT2AMEN1BLMSLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2811997-B1 | SUBSTITUTED PROLINES/PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | EOLAS THERAPEUTICS INC (US) | 2018-04-11 | — | — | EP | disclosed |