Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 18/20 | 0.61 |
| ▸ | HCRTR2 | O43614 | 15/20 | 0.61 |
| ▸ | PREP | P48147 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20040278 | 1.00 | HCRTR1 (0.61) | HCRTR1HCRTR2PREPKDM4EPOLB | |
| SCHEMBL15184286 | 0.84 | HCRTR1 (0.60) | HCRTR1HCRTR2PREPKDM4EPOLB | |
| SCHEMBL16279291 | 0.84 | HCRTR1 (0.60) | HCRTR1HCRTR2PREPKDM4EPOLB | |
| SCHEMBL6980865 | 0.83 | KDM4E (0.61) | HCRTR1HCRTR2PREPKDM4EPOLB | |
| SCHEMBL5230555 | 0.82 | CNR1 (0.63) | HCRTR1HCRTR2KDM4E | |
| SCHEMBL1571858 | 0.80 | HCRTR1 (0.49) | HCRTR1HCRTR2 | |
| SCHEMBL20040255 | 0.79 | HCRTR1 (0.95) | HCRTR1HCRTR2 | |
| SCHEMBL20040316 | 0.79 | HCRTR1 (0.95) | HCRTR1HCRTR2 | |
| SCHEMBL14410594 | 0.78 | KDM1A (0.46) | HCRTR1HCRTR2KDM4EPOLB | |
| SCHEMBL4664834 | 0.78 | KDM4E (0.65) | HCRTR1HCRTR2PREPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2811997-B1 | SUBSTITUTED PROLINES/PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | EOLAS THERAPEUTICS INC (US) | 2018-04-11 | — | — | EP | disclosed |