Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.42 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.40 |
| ▸ | POLA1 | P09884 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2284751 | 0.86 | NPC1 (0.56) | NPC1MKNK1SCN9AMAPK1EGFR | |
| SCHEMBL690919 | 0.81 | NPC1 (0.55) | NPC1MKNK1MAPK1EGFRERBB3 | |
| SCHEMBL22328022 | 0.79 | NPC1 (0.64) | NPC1MKNK1SCN9AMAPK1EGFR | |
| SCHEMBL4663995 | 0.79 | NPC1 (0.64) | NPC1MKNK1SCN9AEGFRERBB3 | |
| SCHEMBL15542527 | 0.76 | NPC1 (0.47) | NPC1MKNK1EGFRERBB3TNNI3K | |
| SCHEMBL2283204 | 0.75 | NPC1 (0.68) | NPC1MKNK1SCN9AEGFRERBB3 | |
| SCHEMBL2279563 | 0.75 | MEN1 (0.56) | NPC1MKNK1MAPK1EGFRERBB3 | |
| SCHEMBL20093470 | 0.75 | NPC1 (0.51) | NPC1MKNK1EGFRERBB3TNNI3K | |
| SCHEMBL1095277 | 0.74 | MAPK1 (0.61) | SCN9AMAPK1EGFRERBB3GRM1 | |
| Hydrochloric Acid SCHEMBL2176150 | 0.74 | NPC1 (0.66) | NPC1MKNK1SCN9AEGFRERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864289-B1 | CYCLOPROPANECARBOXAMIDO-SUBSTITUTED AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS | CB THERAPEUTICS INC (KY) | 2018-04-11 | — | — | EP | disclosed |