Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.74 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.60 |
| ▸ | TNNI3K | Q59H18 | 7/20 | 0.60 |
| ▸ | BRAF | P15056 | 6/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16904584 | 0.85 | KDR (1.00) | KDRBRAF | |
| SCHEMBL20040931 | 0.78 | KDR (0.64) | KDRMAPK14TNNI3KBRAF | |
| SCHEMBL16904586 | 0.77 | KDR (1.00) | KDRBRAF | |
| SCHEMBL16904585 | 0.73 | KDR (1.00) | KDRMAPK14TNNI3KBRAF | |
| SCHEMBL20040928 | 0.72 | KDR (0.68) | KDRBRAF | |
| SCHEMBL16907545 | 0.72 | KDR (1.00) | KDRBRAF | |
| SCHEMBL14014127 | 0.71 | MTOR (0.57) | KDRBRAF | |
| SCHEMBL19398200 | 0.69 | PSEN1 (0.56) | KDRBRAF | |
| SCHEMBL16904583 | 0.69 | KDR (1.00) | KDRBRAF | |
| SCHEMBL12513194 | 0.66 | MAPT (0.83) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864289-B1 | CYCLOPROPANECARBOXAMIDO-SUBSTITUTED AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS | CB THERAPEUTICS INC (KY) | 2018-04-11 | — | — | EP | disclosed |