Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.71 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.62 |
| ▸ | TUBB | P07437 | 1/20 | 0.62 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.62 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.62 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.62 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.62 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.62 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.62 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.62 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.62 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.62 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.62 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.62 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.62 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.62 |
| ▸ | BRAF | P15056 | 3/20 | 0.59 |
| ▸ | MAP2K7 | O14733 | 4/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16904591 | 0.83 | KDR (1.00) | KDRBRAF | |
| SCHEMBL16904528 | 0.83 | KDR (0.63) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL16904592 | 0.83 | KDR (1.00) | KDRBRAFMAPK14TNNI3K | |
| SCHEMBL13777941 | 0.80 | KDR (0.81) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL16904594 | 0.80 | KDR (1.00) | KDRBRAF | |
| SCHEMBL16904593 | 0.80 | KDR (1.00) | KDRBRAF | |
| SCHEMBL16904578 | 0.79 | KDR (1.00) | KDRBRAF | |
| SCHEMBL20040907 | 0.78 | KDR (0.90) | KDRBRAF | |
| SCHEMBL16904587 | 0.78 | KDR (1.00) | KDRBRAF | |
| SCHEMBL16907508 | 0.78 | KDR (1.00) | KDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864289-B1 | CYCLOPROPANECARBOXAMIDO-SUBSTITUTED AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS | CB THERAPEUTICS INC (KY) | 2018-04-11 | — | — | EP | disclosed |