Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 5/20 | 0.32 |
| ▸ | KDM5C | P41229 | 5/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.31 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15994045 | 0.85 | CHRM2 (0.36) | KDM5AKDM5CKDM5BSIRT2KDM6B | |
| SCHEMBL16006935 | 0.85 | CYP3A4 (0.33) | KDM5AKDM5CKDM5BBACE1 | |
| SCHEMBL17984964 | 0.85 | CYP3A4 (0.33) | KDM5AKDM5CKDM5BBACE1 | |
| SCHEMBL17984968 | 0.85 | CYP3A4 (0.33) | KDM5AKDM5CKDM5BBACE1 | |
| SCHEMBL15994044 | 0.85 | CHRM2 (0.36) | KDM5AKDM5CKDM5BSIRT2KDM6B | |
| SCHEMBL17984966 | 0.85 | CYP3A4 (0.33) | KDM5AKDM5CKDM5BBACE1 | |
| SCHEMBL16303319 | 0.84 | CYP3A4 (0.31) | KDM5AKDM5CKDM5BKDM6BKDM4A | |
| SCHEMBL16006931 | 0.84 | CHRM2 (0.39) | KDM5AKDM5CKDM5BSIRT2KDM6B | |
| SCHEMBL15994175 | 0.84 | CHRM2 (0.39) | KDM5AKDM5CKDM5BSIRT2KDM6B | |
| SCHEMBL15994123 | 0.84 | CYP3A4 (0.31) | KDM5AKDM5CKDM5BKDM6BKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2961736-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2018-04-11 | — | — | EP | disclosed |