Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.61 |
| ▸ | MTOR | P42345 | 3/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.46 |
| ▸ | CFTR | P13569 | 3/20 | 0.45 |
| ▸ | CKS1B | P61024 | 2/20 | 0.43 |
| ▸ | SKP1 | P63208 | 2/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042814 | 0.81 | CFTR (0.52) | GBA1CFTRPDE10AUSP2ALDH1A1 | |
| SCHEMBL19358268 | 0.80 | MTOR (0.59) | GBA1MTORGPR119PDE10AALDH1A1 | |
| SCHEMBL1261149 | 0.78 | GBA1 (0.51) | GBA1MTORKITGPR119PDE10A | |
| SCHEMBL416075 | 0.78 | PDE10A (0.52) | GBA1GPR119PDE10AMAPT | |
| SCHEMBL20042972 | 0.77 | MTOR (0.47) | GBA1MTORGPR119CKS1BSKP1 | |
| SCHEMBL20042670 | 0.77 | MTOR (0.47) | MTORGPR119CKS1BSKP1SKP2 | |
| SCHEMBL31614795 | 0.77 | MTOR (0.47) | MTORGPR119CKS1BSKP1SKP2 | |
| SCHEMBL20042815 | 0.76 | MTOR (0.46) | GBA1MTORGPR119CKS1BSKP1 | |
| SCHEMBL31516224 | 0.76 | MTOR (0.46) | GBA1MTORGPR119CKS1BSKP1 | |
| SCHEMBL18353954 | 0.76 | GBA1 (1.00) | GBA1KITCKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |