Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20043335 | 0.97 | NR1H4 (0.65) | NR1H4 | |
| SCHEMBL20049079 | 0.92 | NR1H4 (0.57) | NR1H4 | |
| SCHEMBL20048943 | 0.91 | NR1H4 (0.65) | NR1H4 | |
| SCHEMBL20048923 | 0.90 | NR1H4 (0.55) | NR1H4 | |
| SCHEMBL20049096 | 0.89 | NR1H4 (0.53) | NR1H4 | |
| SCHEMBL20049137 | 0.89 | NR1H4 (0.57) | NR1H4 | |
| SCHEMBL20043333 | 0.89 | NR1H4 (0.59) | NR1H4 | |
| SCHEMBL20049130 | 0.89 | NR1H4 (0.55) | NR1H4 | |
| SCHEMBL20048957 | 0.88 | NR1H4 (0.68) | NR1H4 | |
| SCHEMBL20043506 | 0.88 | NR1H4 (0.65) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067704-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |