Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 18/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049527 | 0.86 | STING1 (0.66) | STING1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL22567010 | 0.84 | STING1 (0.82) | STING1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29636380 | 0.75 | HDAC3 (0.73) | STING1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12723471 | 0.75 | HDAC3 (0.73) | STING1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29362434 | 0.74 | STING1 (1.00) | STING1ACHE | |
| SCHEMBL21405886 | 0.74 | STING1 (0.79) | STING1ACHE | |
| SCHEMBL20022176 | 0.74 | STING1 (0.79) | STING1ACHE | |
| SCHEMBL9208326 | 0.74 | STING1 (1.00) | STING1ACHE | |
| SCHEMBL20022337 | 0.74 | STING1 (0.81) | STING1ACHE | |
| SCHEMBL30820009 | 0.74 | STING1 (0.81) | STING1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067423-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-12 | — | — | WO | disclosed |