Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.38 |
| ▸ | ADCY5 | O95622 | 5/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | NNMT | P40261 | 5/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18572584 | 1.00 | PIP4K2A (0.39) | PIP4K2APRMT5WDR77ADCY5SLC22A12 | |
| SCHEMBL9950030 | 0.92 | PIP4K2A (0.42) | PIP4K2APRMT5WDR77SLC22A12NNMT | |
| SCHEMBL1441891 | 0.92 | PIP4K2A (0.42) | PIP4K2APRMT5WDR77SLC22A12NNMT | |
| SCHEMBL25049187 | 0.87 | PIP4K2A (0.39) | PIP4K2APRMT5WDR77ADCY5SLC22A12 | |
| SCHEMBL25047393 | 0.85 | PRMT5 (0.40) | PIP4K2APRMT5WDR77ADCY5ACACB | |
| SCHEMBL19344041 | 0.85 | ADCY5 (0.47) | PRMT5WDR77ADCY5 | |
| SCHEMBL23584600 | 0.85 | ADCY5 (0.47) | PRMT5WDR77ADCY5 | |
| SCHEMBL10236925 | 0.85 | ADCY5 (0.47) | PRMT5WDR77ADCY5 | |
| SCHEMBL16967987 | 0.83 | PIP4K2A (0.49) | PIP4K2APRMT5WDR77SLC22A12ACACB | |
| SCHEMBL18571707 | 0.83 | ABL1 (0.44) | PIP4K2APRMT5WDR77SLC22A12NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |
| WO-2018065365-A1 | NOVEL MONOCYCLIC AND BICYCLIC RING SYSTEM SUBSTITUTED CARBANUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |