Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 11/20 | 0.74 |
| ▸ | RET | P07949 | 8/20 | 0.74 |
| ▸ | BRAF | P15056 | 2/20 | 0.74 |
| ▸ | STK10 | O94804 | 1/20 | 0.74 |
| ▸ | ABL1 | P00519 | 1/20 | 0.74 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.74 |
| ▸ | FLT1 | P17948 | 1/20 | 0.74 |
| ▸ | CDK11B | P21127 | 1/20 | 0.74 |
| ▸ | CDK2 | P24941 | 1/20 | 0.74 |
| ▸ | FLT4 | P35916 | 1/20 | 0.74 |
| ▸ | KDR | P35968 | 1/20 | 0.74 |
| ▸ | FLT3 | P36888 | 1/20 | 0.74 |
| ▸ | CDK7 | P50613 | 1/20 | 0.74 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.74 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.74 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.74 |
| ▸ | TEK | Q02763 | 1/20 | 0.74 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.74 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.74 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25639500 | 0.88 | KIT (0.84) | KITRETBRAFSTK10ABL1 | |
| SCHEMBL1696182 | 0.87 | KIT (0.85) | KITRETBRAFSTK10ABL1 | |
| SCHEMBL25639509 | 0.86 | KIT (0.83) | KITRETBRAFSTK10ABL1 | |
| SCHEMBL29381604 | 0.85 | KIT (1.00) | KITRETBRAFSTK10ABL1 | |
| SCHEMBL1696293 | 0.85 | KIT (0.85) | KITRETBRAFSTK10ABL1 | |
| SCHEMBL31060759 | 0.85 | KIT (1.00) | KITRETBRAFSTK10ABL1 | |
| SCHEMBL1696179 | 0.85 | KIT (1.00) | KITRETBRAFSTK10ABL1 | |
| SCHEMBL1696348 | 0.84 | KIT (0.79) | KITRETBRAFSTK10ABL1 | |
| SCHEMBL1696346 | 0.84 | KIT (0.78) | KITRETBRAFSTK10ABL1 | |
| SCHEMBL1696298 | 0.83 | RET (0.76) | KITRETBRAFSTK10ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066545-A1 | HETEROCYCLIC COMPOUND | 公益財団法人ヒューマンサイエンス振興財団 | 2018-04-12 | — | — | WO | disclosed |