Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.52 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.45 |
| ▸ | PDE4A | P27815 | 5/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28034346 | 0.87 | PDE4B (0.53) | NR1H4PARP15PARP10PARP2MAP4K4 | |
| SCHEMBL17204548 | 0.84 | ESR1 (0.48) | NR1H4PARP15PARP10PARP2MAP4K4 | |
| SCHEMBL6051023 | 0.84 | HTT (0.54) | NR1H4PARP15PARP10PARP2MAP4K4 | |
| SCHEMBL2804683 | 0.83 | DPP4 (0.48) | NR1H4PARP15PARP10PARP2MAP4K4 | |
| SCHEMBL662159 | 0.83 | TTR (0.50) | NR1H4PARP15PARP10PARP2MAP4K4 | |
| SCHEMBL17050363 | 0.83 | NR1H4 (0.48) | NR1H4PARP15PARP10PARP2MAP4K4 | |
| SCHEMBL10148399 | 0.83 | KDM5A (0.54) | NR1H4PARP15PARP10PARP2MAP4K4 | |
| SCHEMBL1031663 | 0.82 | CA12 (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL17204380 | 0.82 | PARP15 (0.55) | PARP15PARP10PARP2PDE4BPDE4A | |
| SCHEMBL30575456 | 0.82 | CA12 (0.63) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944612-B2 | 1-phenyl-2-pyridinyl alkyl alcohol derivatives as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-04-17 | — | — | US | disclosed |