Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.42 |
| ▸ | BTK | Q06187 | 14/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CD69 | Q07108 | 1/20 | 0.38 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.38 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.38 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.38 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.38 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20053900 | 0.91 | BTK (0.43) | AAK1BTKJAK2CYP3A4HRH2 | |
| SCHEMBL20053917 | 0.88 | AAK1 (0.47) | AAK1BTKJAK2CYP3A4HRH2 | |
| SCHEMBL20053961 | 0.87 | MAPK1 (0.40) | MAPK1BTKJAK2CDK7CCNA2 | |
| SCHEMBL20461151 | 0.84 | BTK (0.61) | MAPK1AAK1BTKJAK2CYP3A4 | |
| SCHEMBL20053927 | 0.83 | AAK1 (0.45) | AAK1BTK | |
| SCHEMBL20054038 | 0.79 | BTK (0.46) | AAK1BTKJAK2CYP3A4HRH2 | |
| SCHEMBL20054045 | 0.78 | AAK1 (0.47) | AAK1BTK | |
| SCHEMBL20053902 | 0.78 | AAK1 (0.46) | AAK1BTKJAK2CYP3A4HRH2 | |
| SCHEMBL20461227 | 0.76 | BTK (0.58) | AAK1BTKJAK2CYP3A4HRH2 | |
| SCHEMBL20461157 | 0.76 | BTK (0.36) | MAPK1AAK1BTKJAK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3357921-A2 | BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY | Sunesis Pharmaceuticals, Inc. (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-3080103-B1 | BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY | BIOGEN MA INC (US) | 2018-04-18 | — | — | EP | disclosed |