Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16794185 | 0.89 | BTK (0.44) | BTKKLKB1HPGDAAK1 | |
| SCHEMBL25173924 | 0.88 | BTK (0.52) | BTKKLKB1AAK1 | |
| SCHEMBL20054061 | 0.79 | BTK (0.52) | BTKAAK1 | |
| SCHEMBL25173694 | 0.77 | BTK (0.46) | BTK | |
| SCHEMBL16794278 | 0.74 | BTK (0.62) | BTKAAK1 | |
| SCHEMBL30913578 | 0.74 | BTK (0.56) | BTKKLKB1 | |
| SCHEMBL25173782 | 0.74 | BTK (0.56) | BTKKLKB1 | |
| SCHEMBL29676565 | 0.73 | BTK (0.65) | BTKAAK1 | |
| SCHEMBL16794335 | 0.73 | BTK (0.60) | BTKAAK1 | |
| SCHEMBL16794097 | 0.73 | BTK (0.65) | BTKAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080103-B1 | BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY | BIOGEN MA INC (US) | 2018-04-18 | — | — | EP | disclosed |