Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.51 |
| ▸ | PPARG | P37231 | 8/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13078733 | 0.86 | ESR1 (0.61) | EPHX2PPARGESR1ESR2CA1 | |
| SCHEMBL3662079 | 0.86 | ESR1 (0.61) | EPHX2PPARGESR1ESR2CA1 | |
| SCHEMBL19647120 | 0.86 | CXCR1 (0.50) | EPHX2PPARGESR1ESR2CA1 | |
| SCHEMBL3870170 | 0.86 | ESR1 (0.61) | EPHX2PPARGESR1ESR2CA1 | |
| SCHEMBL28201178 | 0.85 | EPHX2 (0.64) | EPHX2PPARGPPARAPPARDKMT2A | |
| SCHEMBL1887761 | 0.85 | HDAC1 (0.50) | EPHX2PPARGPPARAPPARDESR1 | |
| SCHEMBL28394857 | 0.85 | ATM (0.47) | EPHX2PPARGATML3MBTL1PPARA | |
| SCHEMBL6987684 | 0.85 | EPHX2 (0.47) | EPHX2PPARGPPARAESR1ESR2 | |
| SCHEMBL117431 | 0.84 | CYP1A2 (0.60) | EPHX2PPARGATMPPARAMEN1 | |
| SCHEMBL17054207 | 0.82 | CXCR1 (0.50) | EPHX2PPARGPPARAPPARDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780039-B9 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2018-04-18 | — | — | EP | disclosed |