Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.62 |
| ▸ | CACNA1I | Q9P0X4 | 6/20 | 0.62 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22019054 | 0.93 | KCNH2 (0.55) | KCNH2CACNA1IMCHR1RORCCCR2 | |
| SCHEMBL19113143 | 0.92 | KCNH2 (0.54) | KCNH2CACNA1IMCHR1HTR1AADRA2A | |
| SCHEMBL1432591 | 0.88 | KCNH2 (0.62) | KCNH2CACNA1IMCHR1HTR1AADRA2A | |
| SCHEMBL4278214 | 0.85 | KCNH2 (0.59) | KCNH2CACNA1IMCHR1HTR1AADRA2A | |
| SCHEMBL19112548 | 0.85 | KCNH2 (0.62) | KCNH2CACNA1IMCHR1HTR1AADRA2A | |
| SCHEMBL4269237 | 0.84 | KCNH2 (0.64) | KCNH2CACNA1IMCHR1RORCCCR2 | |
| SCHEMBL1428162 | 0.84 | KCNH2 (0.64) | KCNH2CACNA1IMCHR1HTR1AADRA2A | |
| SCHEMBL1427922 | 0.83 | KCNH2 (0.76) | KCNH2CACNA1IMCHR1CCR2 | |
| SCHEMBL4274233 | 0.83 | KCNH2 (0.62) | KCNH2CACNA1IMCHR1RORCCCR2 | |
| SCHEMBL4274637 | 0.83 | KCNH2 (0.62) | KCNH2CACNA1IMCHR1RORCCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-2300007-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TARO PHARMACEUTICALS INC (CA) | 2018-04-18 | — | — | EP | disclosed |