Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20056226 | 0.86 | BACE1 (0.52) | BACE1BACE2 | |
| SCHEMBL17127320 | 0.84 | BACE1 (0.70) | BACE1BACE2 | |
| SCHEMBL20056278 | 0.84 | BACE1 (0.51) | BACE1BACE2 | |
| SCHEMBL20056568 | 0.84 | BACE1 (0.53) | BACE1BACE2 | |
| SCHEMBL20056572 | 0.83 | BACE1 (0.50) | BACE1BACE2 | |
| SCHEMBL20056457 | 0.81 | BACE1 (0.52) | BACE1BACE2 | |
| SCHEMBL20056276 | 0.81 | BACE1 (0.54) | BACE1BACE2 | |
| SCHEMBL20056210 | 0.79 | BACE1 (0.57) | BACE1BACE2 | |
| SCHEMBL20056448 | 0.79 | BACE1 (0.55) | BACE1BACE2 | |
| SCHEMBL20056555 | 0.79 | BACE1 (0.53) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2908825-B1 | TRICYCLIC SUBSTITUTED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2018-04-18 | — | — | EP | disclosed |