Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 16/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 15/20 | 0.66 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.65 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.53 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4269542 | 0.93 | CACNA1I (0.67) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL13569869 | 0.91 | CACNA1I (0.63) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL4271477 | 0.88 | CACNA1I (0.62) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL22019442 | 0.86 | CACNA1I (0.71) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL4272178 | 0.86 | CACNA1I (0.77) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL14770038 | 0.86 | CACNA1I (0.62) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL4278588 | 0.86 | CACNA1I (0.59) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL19113071 | 0.85 | CACNA1I (0.60) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL4275111 | 0.84 | CACNA1I (0.59) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G | |
| SCHEMBL4285578 | 0.84 | KCNH2 (0.78) | CACNA1IKCNH2CACNA1HCYP2D6CACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-2300007-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TARO PHARMACEUTICALS INC (CA) | 2018-04-18 | — | — | EP | disclosed |