Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 17/20 | 0.77 |
| ▸ | PRKDC | P78527 | 1/20 | 0.77 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10142563 | 1.00 | PIK3CG (0.77) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL19446166 | 1.00 | PIK3CG (0.77) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL19446154 | 0.94 | PIK3CG (0.69) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL10142710 | 0.93 | PIK3CG (0.67) | PIK3CGPRKDCPIK3CDPIK3CA | |
| SCHEMBL10143064 | 0.93 | PIK3CG (0.67) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL10143288 | 0.92 | PIK3CG (0.65) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL10143102 | 0.92 | PIK3CG (0.65) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL10143289 | 0.92 | PIK3CG (0.65) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL10142701 | 0.92 | PIK3CG (0.67) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL19446349 | 0.92 | PIK3CG (0.67) | PIK3CGPRKDCPIK3CDPIK3CATTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3808739-A1 | ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | Vertex Pharmaceuticals Incorporated (US) | 2021-04-21 | — | — | EP | disclosed |
| EP-3309152-A1 | ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | Vertex Pharmaceuticals Incorporated (US) | 2018-04-18 | — | — | EP | disclosed |