SCHEMBL2005892

SCHEMBL2005892

Cc1cc(C(F)(C(F)(F)F)C(F)(F)F)cc(C)c1NC(=O)c1cccc(NC(=O)c2ccccc2Cl)c1

nearest known ligand 0.61

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 5/20 0.61
KCNK9 Q9NPC2 5/20 0.61
MAPT P10636 1/20 0.56
MEN1 O00255 1/20 0.55
KMT2A Q03164 1/20 0.55
PTGES O14684 1/20 0.54
TP53 P04637 1/20 0.54
RXFP1 Q9HBX9 3/20 0.53
RORC P51449 1/20 0.49
SMO Q99835 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2261736 0.91 KCNK3 (0.60) KCNK3KCNK9MAPTMEN1KMT2A
SCHEMBL12570375 0.88 KCNK3 (0.59) KCNK3KCNK9MAPTMEN1KMT2A
SCHEMBL29409938 0.88 KCNK3 (0.59) KCNK3KCNK9MAPTMEN1KMT2A
SCHEMBL13721775 0.87 KCNK3 (0.67) KCNK3KCNK9MAPTMEN1KMT2A
SCHEMBL1819533 0.85 KCNK3 (0.54) KCNK3KCNK9MAPTMEN1KMT2A
SCHEMBL10144663 0.85 KMT2A (0.50) KCNK3KCNK9MAPTMEN1KMT2A
SCHEMBL1766804 0.84 MAPT (0.55) KCNK3KCNK9MAPTMEN1KMT2A
SCHEMBL1766340 0.84 RXFP1 (0.53) KCNK3KCNK9MAPTMEN1KMT2A
SCHEMBL12348587 0.82 CSF1R (0.48) KCNK3KCNK9MEN1KMT2APTGES
SCHEMBL16863615 0.82 KCNK3 (0.55) KCNK3KCNK9MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2535327-A1 Insecticidal 3-acylaminobenzanilides Bayer CropScience AG (DE) 2012-12-19 EP disclosed
EP-2535327-A1 Insecticidal 3-acylaminobenzanilides Bayer CropScience AG (DE) 2012-12-19 EP disclosed
US-7964735-B2 Insecticidal 3-acylaminobenzanilides BAYER CROPSCIENCE AG (DE) 2011-06-21 US disclosed
US-7964735-B2 Insecticidal 3-acylaminobenzanilides BAYER CROPSCIENCE AG (DE) 2011-06-21 US disclosed
US-20090215623-A1 Insecticidal 3-acylaminobenzanilides BAYER CROPSCIENCE AG (DE) 2009-08-27 US disclosed
US-20090215623-A1 Insecticidal 3-acylaminobenzanilides BAYER CROPSCIENCE AG (DE) 2009-08-27 US disclosed
EP-1912933-A1 INSECTICIDAL 3-ACYLAMINOBENZANILIDES Bayer CropScience AG (DE) 2008-04-23 EP disclosed
WO-2007017075-A1 INSECTICIDAL 3-ACYLAMINOBENZANILIDES BAYER CROPSCIENCE AG (DE) 2007-02-15 WO disclosed
WO-2007017075-A1 INSECTICIDAL 3-ACYLAMINOBENZANILIDES BAYER CROPSCIENCE AG (DE) 2007-02-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090215623-A1 Insecticidal 3-acylaminobenzanilides CBR3, AADAC, DDT KCNK3 65/4885KCNK9 354/4885MAPT 4817/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.