Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 20/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16092157 | 0.90 | PDE10A (1.00) | PDE10A | |
| SCHEMBL20059636 | 0.88 | PDE10A (1.00) | PDE10A | |
| SCHEMBL16092044 | 0.88 | PDE10A (1.00) | PDE10A | |
| SCHEMBL16050122 | 0.88 | PDE10A (1.00) | PDE10A | |
| SCHEMBL16050045 | 0.87 | PDE10A (0.83) | PDE10A | |
| SCHEMBL20059890 | 0.84 | PDE10A (1.00) | PDE10A | |
| SCHEMBL16092046 | 0.84 | PDE10A (1.00) | PDE10A | |
| SCHEMBL20059886 | 0.84 | PDE10A (1.00) | PDE10A | |
| SCHEMBL20059663 | 0.84 | PDE10A (1.00) | PDE10A | |
| SCHEMBL16049967 | 0.84 | PDE10A (1.00) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968324-B1 | SUBSTITUTED PYRIDAZINONE DERIVATIVES AS PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2018-04-18 | — | — | EP | disclosed |