Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 10/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19775515 | 0.88 | PTPRB (0.77) | PTPRBKDM4ERAB9ALMNAGAA | |
| SCHEMBL500149 | 0.88 | PTPRB (1.00) | PTPRB | |
| SCHEMBL468343 | 0.88 | PTPRB (1.00) | PTPRB | |
| SCHEMBL19775430 | 0.86 | PTPRB (0.77) | PTPRBKDM4ERAB9ALMNANPC1 | |
| SCHEMBL21514682 | 0.85 | PTPRB (0.65) | PTPRBKDM4ERAB9AGAATSHR | |
| SCHEMBL19775432 | 0.83 | PTPRB (0.79) | PTPRBKDM4ERAB9ATSHRNPC1 | |
| SCHEMBL20060120 | 0.81 | PTPRB (0.56) | PTPRBKDM4ERAB9ALMNA | |
| SCHEMBL20059874 | 0.80 | PTPRB (0.55) | PTPRB | |
| SCHEMBL24319107 | 0.79 | PTPRB (0.51) | PTPRBKDM4ERAB9ALMNANPC1 | |
| SCHEMBL16239452 | 0.79 | PTPRB (0.85) | PTPRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4101297-A1 | COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES | Aerpio Pharmaceuticals, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| EP-3352856-B1 | ACTIVATORS OF TIE-2 FOR USE IN TREATING INTRAOCULAR PRESSURE | AERPIO PHARMACEUTICALS INC (US) | 2021-08-18 | — | — | EP | disclosed |
| EP-3607821-A1 | COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES | Aerpio Therapeutics, Inc. (US) | 2020-02-12 | — | — | EP | disclosed |
| EP-2967066-B1 | COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES | AERPIO THERAPEUTICS INC (US) | 2019-10-23 | — | — | EP | disclosed |
| EP-2385763-B1 | METHODS FOR TREATING VASCULAR LEAK SYNDROME | AERPIO THERAPEUTICS INC (US) | 2018-04-18 | — | — | EP | disclosed |