Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 10/20 | 0.55 |
| ▸ | CDK2 | P24941 | 6/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.42 |
| ▸ | CDK4 | P11802 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | TTK | P33981 | 2/20 | 0.42 |
| ▸ | CCND3 | P30281 | 2/20 | 0.42 |
| ▸ | PLK1 | P53350 | 2/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10191252 | 0.85 | IGF1R (0.55) | IGF1RCDK2CCNA2CCNA1CDK4 | |
| SCHEMBL20060172 | 0.85 | IGF1R (0.48) | IGF1RCDK2CCNA2CCNA1CDK4 | |
| SCHEMBL20060051 | 0.82 | CDK2 (0.48) | IGF1RCDK2CCNA2CCNA1CDK4 | |
| SCHEMBL20060009 | 0.80 | IGF1R (0.51) | IGF1RCDK2CCNA2CCNA1CDK4 | |
| SCHEMBL20060166 | 0.80 | IGF1R (0.57) | IGF1RCDK2CCNA2CCNA1AURKA | |
| SCHEMBL10191245 | 0.80 | IGF1R (0.65) | IGF1R | |
| SCHEMBL20059940 | 0.79 | IGF1R (0.56) | IGF1RCDK2CCNA2CCNA1AURKA | |
| SCHEMBL20060236 | 0.78 | CDK2 (0.50) | IGF1RCDK2CCNA2CCNA1CDK4 | |
| SCHEMBL20059964 | 0.75 | IGF1R (0.52) | IGF1RCDK2CCNA2CCNA1AURKA | |
| SCHEMBL10191484 | 0.74 | IGF1R (0.63) | IGF1RCDK2CCNA2CCNA1TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595987-B1 | NEW AMINOPYRAZOLOQUINAZOLINES | BOEHRINGER INGELHEIM INT (DE) | 2018-04-18 | — | — | EP | disclosed |