SCHEMBL20060353

SCHEMBL20060353

C1=CC(c2ccc(N(c3ccccc3)c3ccc(-c4ccccc4)cc3)cc2)=CC(c2ccc(N(c3ccccc3)c3ccc(-c4ccccc4)cc3)cc2)C1

nearest known ligand 0.33

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 3/20 0.33
MAOB P27338 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
MAPT P10636 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
HTT P42858 1/20 0.30
BRD4 O60885 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17705326 1.00 KDM1A (0.33) KDM1AMAOBKDM4EALDH1A1CYP1A2
SCHEMBL19593309 0.89 HTR2A (0.31)
SCHEMBL29678250 0.83 SLC18A3 (0.31) KDM1AMAOBMAPTHTT
SCHEMBL22061015 0.81
SCHEMBL19597048 0.81 HTT (0.36) KDM4EALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL19531151 0.81 EDNRB (0.31)
SCHEMBL25056870 0.81
SCHEMBL19381205 0.80
SCHEMBL22619376 0.79 HTT (0.37) KDM4EALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL25012260 0.77 KDM1A (0.33) KDM1AMAOBKDM4EALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3309141-A1 ARYLAMINE COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT Hodogaya Chemical Co., Ltd. (JP) 2018-04-18 EP disclosed