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SCHEMBL20060593

SCHEMBL20060593

CCCCc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)CN(C)C)c3)c3ccccc23)n(-c2ccc(C)cc2)n1

nearest known ligand 0.64

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MAPK12 P53778 14/20 0.64
▸ MAPK14 Q16539 14/20 0.64
▸ HCK P08631 13/20 0.64
▸ GSK3A P49840 5/20 0.64
▸ SRC P12931 5/20 0.64
▸ SYK P43405 3/20 0.64
▸ GSK3B P49841 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20060660 0.92 MAPK14 (0.64) MAPK12MAPK14HCKGSK3ASRC
SCHEMBL19388864 0.91 MAPK14 (0.78) MAPK12MAPK14HCKGSK3ASRC
SCHEMBL20060711 0.91 MAPK14 (0.65) MAPK12MAPK14HCKGSK3ASRC
SCHEMBL12288114 0.91 MAPK14 (0.75) MAPK12MAPK14HCKGSK3ASRC
SCHEMBL20060696 0.90 MAPK14 (0.65) MAPK12MAPK14HCKGSK3ASRC
SCHEMBL20060691 0.90 MAPK14 (0.65) MAPK12MAPK14HCKGSK3ASRC
SCHEMBL20060667 0.90 MAPK14 (0.67) MAPK12MAPK14HCKGSK3ASRC
SCHEMBL20036718 0.90 MAPK14 (0.64) MAPK12MAPK14HCKGSK3ASRC
SCHEMBL20060613 0.88 MAPK12 (0.69) MAPK12MAPK14HCKGSK3ASRC
SCHEMBL20060619 0.88 MAPK14 (0.61) MAPK12MAPK14HCKGSK3ASRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582433-B1 UREIDO-PYRAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF RHINOVIRUS INFECTIONS RESPIVERT LTD (GB) 2018-04-18 — — EP disclosed