SCHEMBL20062365

SCHEMBL20062365

c1ccc2c(c1)-c1cc3cccnc3cc1-c1cccc(-n3c4ccccc4c4ccccc43)c1-c1ccccc1-2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DUSP3 P51452 1/20 0.36
PDGFRB P09619 1/20 0.35
PDGFRA P16234 1/20 0.35
CYP3A4 P08684 2/20 0.35
IDO1 P14902 1/20 0.34
NPC1 O15118 2/20 0.34
POLB P06746 2/20 0.34
PSMD14 O00487 1/20 0.34
TP53 P04637 1/20 0.34
MMP2 P08253 1/20 0.34
GSK3B P49841 1/20 0.33
CDK5 Q00535 1/20 0.33
CDK5R1 Q15078 1/20 0.33
ALDH1A1 P00352 3/20 0.33
RAB9A P51151 1/20 0.33
CYP1B1 Q16678 1/20 0.32
PTPN1 P18031 1/20 0.32
CASP6 P55212 1/20 0.32
HPGD P15428 2/20 0.32
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20062361 1.00 DUSP3 (0.36) DUSP3PDGFRBPDGFRACYP3A4IDO1
SCHEMBL20062358 1.00 DUSP3 (0.36) DUSP3PDGFRBPDGFRACYP3A4IDO1
SCHEMBL20062363 1.00 DUSP3 (0.36) DUSP3PDGFRBPDGFRACYP3A4IDO1
SCHEMBL20062353 0.97 DUSP3 (0.36) DUSP3PDGFRBPDGFRACYP3A4IDO1
SCHEMBL20062366 0.97 DUSP3 (0.36) DUSP3PDGFRBPDGFRACYP3A4IDO1
SCHEMBL20062402 0.83 MAPT (0.40) DUSP3CYP3A4IDO1ALDH1A1PTPN1
SCHEMBL20062401 0.83 MAPT (0.40) DUSP3CYP3A4IDO1ALDH1A1PTPN1
SCHEMBL20062400 0.83 MAPT (0.40) DUSP3CYP3A4IDO1ALDH1A1PTPN1
SCHEMBL20062396 0.82 MAPT (0.39) DUSP3CYP3A4IDO1ALDH1A1PTPN1
SCHEMBL20062407 0.82 MAPT (0.39) DUSP3CYP3A4IDO1ALDH1A1PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10608185-B2 Organic electroluminescent materials and devices UNIVERAL DISPLAY CORPORATION (US) 2020-03-31 US disclosed
US-20180108844-A1 Organic Electroluminescent Materials and Devices UNIVERSAL DISPLAY CORPORATION 2018-04-19 US disclosed
US-20180108844-A1 Organic Electroluminescent Materials and Devices UNIVERSAL DISPLAY CORPORATION 2018-04-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180108844-A1 Organic Electroluminescent Materials and Devices SLCO4C1, SLCO2A1, SLCO2B1 DUSP3 4268/4885PDGFRB 4738/4885PDGFRA 4445/4885
US-10608185-B2 Organic electroluminescent materials and devices SLCO4C1, SLCO2A1, SLCO2B1 DUSP3 4268/4885PDGFRB 4738/4885PDGFRA 4445/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.