Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.44 |
| ▸ | PDE4A | P27815 | 10/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21222215 | 0.88 | PDE4D (0.43) | PDE4DPDE4BPDE4APDE4CIDO1 | |
| SCHEMBL20063990 | 0.88 | PDE4D (0.43) | PDE4DPDE4BPDE4APDE4CIDO1 | |
| SCHEMBL20064124 | 0.87 | PDE4D (0.43) | PDE4DPDE4BPDE4APDE4CSLC6A4 | |
| SCHEMBL21222626 | 0.87 | PDE4D (0.43) | PDE4DPDE4BPDE4APDE4CSLC6A4 | |
| SCHEMBL21227936 | 0.86 | PDE4D (0.42) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL21227833 | 0.86 | PDE4D (0.43) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL21227907 | 0.86 | PDE4D (0.42) | PDE4DPDE4BPDE4APDE4CIDO1 | |
| SCHEMBL21227928 | 0.80 | PDE4D (0.40) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL20064976 | 0.79 | KMT2A (0.40) | PDE4DPDE4BPDE4APDE4CIDO1 | |
| SCHEMBL21222444 | 0.78 | SLC6A4 (0.39) | PDE4DPDE4BPDE4APDE4CIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |