Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21241481 | 0.85 | USP2 (0.44) | DDB1CRBNNR1H2MAPTMEN1 | |
| SCHEMBL104498 | 0.85 | USP2 (0.44) | DDB1CRBNNR1H2MAPTMEN1 | |
| SCHEMBL28441771 | 0.85 | USP2 (0.44) | DDB1CRBNNR1H2MAPTMEN1 | |
| Ammonia Solution, Strong SCHEMBL28305195 | 0.84 | USP2 (0.42) | DDB1CRBNNR1H2MAPTMEN1 | |
| SCHEMBL16825886 | 0.81 | DDB1 (0.43) | DDB1CRBNNR1H2MAPTMEN1 | |
| SCHEMBL20067485 | 0.80 | DDB1 (0.33) | DDB1CRBNNR1H2MAPTMEN1 | |
| SCHEMBL20971792 | 0.79 | DDB1 (0.41) | DDB1CRBNNR1H2MAPTMEN1 | |
| SCHEMBL19331754 | 0.79 | DDB1 (0.44) | DDB1CRBNNR1H2MAPTMEN1 | |
| SCHEMBL31339121 | 0.79 | NR1H2 (0.49) | DDB1CRBNNR1H2MAPTMEN1 | |
| SCHEMBL656014 | 0.79 | DDB1 (0.44) | DDB1CRBNNR1H2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071404-A1 | INHIBITORS OF MUTANT ISOCITRATE DEHYDROGENASES AND COMPOSITIONS AND METHODS THEREOF | ISOCURE BIOSCIENCES INC. (US) | 2018-04-19 | — | — | WO | disclosed |